Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment

Abstract EN

Purpose.

We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro.

Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD.

Methods.

The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD.

The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis.

Results.

The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were 23.68±43.00, 12.07±15.36 days, 155.85±86.67 degrees, and 37000±67100 pixels, respectively.

Five eyes with RRD had vitreous hemorrhage preoperatively.

The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β=0.699) and the time from onset of RRD to vitrectomy (β=0.358) but not with the range of RD or presence of vitreous hemorrhage.

Conclusion.

The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration.