H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease
Joint Authors
Li, Tan
Fang, Qi
Duan, Xiaoyu
Diao, Shanshan
Yang, Si
Kong, Yan
Cai, Xiuying
Liu, Xueyun
Liu, Sanjiao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The correlation between H-type hypertension and cerebral small-vessel diseases (CSVD) remains uncertain.
Objective.
The present study was designed to explore the possible relationship between H-type hypertension and CSVD spectrum and total burden.
Method.
We included 329 patients in the present study and divided them into four groups: the H-type hypertension group, isolated hypertension group, isolated hyperhomocysteinemia (HHcy) group, and control group.
Clinical variables of interest and the MR examination sequences were obtained.
We counted the presence of each CSVD feature and rated the total burden of CSVD on an ordinal scale from 0 to 4 according to a recent described score rule.
Result.
The results showed that H-type hypertension was associated with the presence of cerebral microbleeds (CMBs), and the severity of white-matter hyperintensities (WMHs) and peripheral vascular space (PVS).
CSVD total burden was significantly related to age (OR: 1.059, 95% CI: 1.037–1.082), systolic pressure (OR: 1.122, 95% CI: 1.007–1.136), triglycerides (OR: 1.386, 95% CI: 1.037–1.854), isolated HHcy (OR: 4.154, 95% CI 1.836–9.401), and H-type hypertension (OR: 5.028, 95% CI: 2.323–10.883).
Also, we further observed hypertension and HHcy had a synergistic effect on CSVD total burden (OR: 2.776, 95% CI: 1.564–4.927).
Conclusion.
H-type hypertension was associated with CSVD total burden and CSVD spectrum, which deserves further prevention measures.
Furthermore, hypertension and HHcy had a synergistic effect on CSVD total burden.
American Psychological Association (APA)
Li, Tan& Liu, Xueyun& Diao, Shanshan& Kong, Yan& Duan, Xiaoyu& Yang, Si…[et al.]. 2020. H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135939
Modern Language Association (MLA)
Li, Tan…[et al.]. H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1135939
American Medical Association (AMA)
Li, Tan& Liu, Xueyun& Diao, Shanshan& Kong, Yan& Duan, Xiaoyu& Yang, Si…[et al.]. H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135939