Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter
Joint Authors
Couto, J.
Antunes, S.
Ferrolho, J.
Domingos, A.
de la Fuente, José
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge.
Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites.
The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during Plasmodium infection, and its knockdown decreases the number of sporozoites in mosquito salivary glands.
These results together with the fact that glucose is a vital source of energy suggested that a glucose transporter is a candidate protective antigen for the control of mosquito infestations and Plasmodium infection.
To address this hypothesis, herein we investigate the effect of mice vaccination with an immunogenic peptide from mosquito glucose transporter on Anopheles stephensi fitness and Plasmodium berghei infection.
We showed that vaccination with a peptide of glucose transporter reduced mosquito survival by 5% when compared to controls.
However, the reduction in Plasmodium infection was not significant in mosquitoes fed on vaccinated mice.
The effect of the peptide vaccination on mosquito survival is important to reduce infestation by malaria vectors.
These results support further research on developing glucose transporter-based vaccines to reduce mosquito fitness.
American Psychological Association (APA)
Couto, J.& Antunes, S.& Ferrolho, J.& de la Fuente, José& Domingos, A.. 2017. Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135942
Modern Language Association (MLA)
Couto, J.…[et al.]. Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1135942
American Medical Association (AMA)
Couto, J.& Antunes, S.& Ferrolho, J.& de la Fuente, José& Domingos, A.. Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135942