Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer
Joint Authors
Guerrero, Santiago
Guevara-Ramírez, Patricia
López-Cortés, Andrés
Zambrano, Ana K.
Paz-y-Miño, César
Cabrera-Andrade, Alejandro
Salazar-Ruales, Carolina
Leone, Paola E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Prostate cancer (PC) is the second most commonly diagnosed type of cancer in males with 1,114,072 new cases in 2015.
The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids.
MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage.
Androgens play essential roles in prostate growth.
The SRD5A2 enzyme metabolizes testosterone and the V89L polymorphism reduces in vivo SRD5A2 activity.
The androgen receptor gene codes for a three-domain protein that contains two polymorphic trinucleotide repeats (CAG, GGC).
Therefore, it is essential to know how PC risk is associated with clinical features and polymorphisms in high altitude Ecuadorian mestizo populations.
We analyzed 480 healthy and 326 affected men from our three retrospective case-control studies.
We found significant association between MTHFR C/T (odds ratio [OR] = 2.2; P=0.009), MTHFR C/T+T/T (OR = 2.22; P=0.009), and PC.
The SRD5A2 A49T substitution was associated with higher pTNM stage (OR = 2.88; P=0.039) and elevated Gleason grade (OR = 3.15; P=0.004).
Additionally, patients with ≤21 CAG repeats have an increased risk of developing PC (OR = 2.99; P<0.001).
In conclusion, genotype polymorphism studies are important to characterize genetic variations in high altitude mestizo populations.
American Psychological Association (APA)
López-Cortés, Andrés& Cabrera-Andrade, Alejandro& Salazar-Ruales, Carolina& Zambrano, Ana K.& Guerrero, Santiago& Guevara-Ramírez, Patricia…[et al.]. 2017. Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136025
Modern Language Association (MLA)
López-Cortés, Andrés…[et al.]. Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136025
American Medical Association (AMA)
López-Cortés, Andrés& Cabrera-Andrade, Alejandro& Salazar-Ruales, Carolina& Zambrano, Ana K.& Guerrero, Santiago& Guevara-Ramírez, Patricia…[et al.]. Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136025