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Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient
Joint Authors
Bukhari, Nedal
Azam, Faisal
Alfawaz, Mohammed
Zahrani, Mohammed
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine.
We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy.
She was found to be heterozygous for rs371313778, c.2434G>A.
This finding prompted restarting 5-FU at 50% dose reduction with further titration in subsequent cycles.
We herein report the first case of rs371313778, c.2434G>A (p.Val812lle) DPYD polymorphism leading to severe 5-FU toxicities.
The patient eventually completed a 6-month course of adjuvant treatment with modification of 5-FU dose.
American Psychological Association (APA)
Bukhari, Nedal& Azam, Faisal& Alfawaz, Mohammed& Zahrani, Mohammed. 2019. Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient. Case Reports in Genetics،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136040
Modern Language Association (MLA)
Bukhari, Nedal…[et al.]. Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient. Case Reports in Genetics No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1136040
American Medical Association (AMA)
Bukhari, Nedal& Azam, Faisal& Alfawaz, Mohammed& Zahrani, Mohammed. Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient. Case Reports in Genetics. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136040