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In Vivo Murine Model of Leukemia Cell-Induced Spinal Bone Destruction
Joint Authors
Chen, Jiajie
Zhou, Wei
Cai, Nan
Wu, Jin-peng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteolytic bone lesions can be a consequence of leukemic bone infiltration or focal bone destruction by inflammatory factors released from leukemic cells.
Destructive bone lesions have a negative impact on the quality of life of leukemia patients, causing unbearable pain and, in some cases, limb paralysis.
However, the mechanism, by which leukemic cells produce destructive bone lesions, and the effect of therapeutics on osteolytic lesions have not been fully elucidated yet and, thus, stand to benefit from an in vivo model.
To that end, HL-60 cells were transformed by retrovirus-mediated constitutively active (CA) STAT5 expression and injected into nonobese diabetic (NOD)/SCID mice via the tail vein.
After three weeks, lumbar spines were subjected to histocytometric analysis.
Xenograft mice developed hind limb paralysis in 2-3 weeks, which was consistent with the consequences of spinal bone destruction by extramedullary invasion of leukemia cells.
The in vivo model will improve the understanding and treatment of osteolytic bone lesions caused by myeloid leukemic cells.
American Psychological Association (APA)
Chen, Jiajie& Zhou, Wei& Cai, Nan& Wu, Jin-peng. 2017. In Vivo Murine Model of Leukemia Cell-Induced Spinal Bone Destruction. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1136053
Modern Language Association (MLA)
Chen, Jiajie…[et al.]. In Vivo Murine Model of Leukemia Cell-Induced Spinal Bone Destruction. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1136053
American Medical Association (AMA)
Chen, Jiajie& Zhou, Wei& Cai, Nan& Wu, Jin-peng. In Vivo Murine Model of Leukemia Cell-Induced Spinal Bone Destruction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1136053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136053