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Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units
Joint Authors
Yang, Jie
Kang, Yan
Zhou, Yongfang
Xu, Binbin
Wang, Peng
Lv, Yinxia
Wang, Zhen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Delirium is a primary adverse event in ventilated patients who receive long-term monosedative treatment.
Sequential sedation may reduce these adverse effects.
This study evaluated risk factors for delirium in sequential sedation patients.
Methods.
A total of 141 patients who underwent sequential sedation were enrolled.
Delirium was diagnosed using Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scale.
Univariate and multivariate Cox proportional hazards regressions were used to predict risk factors.
Results.
Older age (≥51) (RR = 2.432, 95% CL 1.316–4.494, p=0.005), higher SOFA score (≥14) (RR = 2.022, 95% CL 1.076–3.798, p=0.029), regular smoking (RR = 2.366, 95% CL 1.277–4.382, p=0.006), and higher maintenance dose of midazolam (RR = 1.052, 95% CL 1.000–1.107, p=0.049) and fentanyl (RR = 1.045, 95% CL 1.019–1.072, p=0.001) when patients met sequential criteria, were independent risk factors of delirium.
Sequential sedation with dexmedetomidine (RR = 0.448, 95% CL 0.209–0.963, p=0.040) was associated with a lower risk of delirium.
Conclusions.
Older age, higher SOFA score, regular smoking, and higher maintenance dose of midazolam and fentanyl when patients met sequential criteria were independent risk factors of delirium in sequential sedation patients.
Sequential sedation with dexmedetomidine reduced risk of delirium.
American Psychological Association (APA)
Yang, Jie& Zhou, Yongfang& Kang, Yan& Xu, Binbin& Wang, Peng& Lv, Yinxia…[et al.]. 2017. Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136065
Modern Language Association (MLA)
Yang, Jie…[et al.]. Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136065
American Medical Association (AMA)
Yang, Jie& Zhou, Yongfang& Kang, Yan& Xu, Binbin& Wang, Peng& Lv, Yinxia…[et al.]. Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136065