Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery

Joint Authors

Zhang, Wei Fen
Zhang, Weifen
Wang, Yong-Hong
Yang, Ting-Ting
Cheng, Yuan-Zheng
Qin, Meng
Wang, An-Lin

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-10-25

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages.

However, burst release of drugs is becoming a critical challenge when the hydrogels are employed.

Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation.

Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL).

The physicochemical properties of the optimal MS (MS F) were characterized.

Depending on the gelation temperature and gelating time, the optimal CTS-sodium alginate- (SA-) α,β-glycerophosphate (GP) (CTS-SA-GP) hydrogel was obtained.

Observed by scanning electron microscope (SEM), TFV/BSP/CTS MS were successfully encapsulated in CTS-SA-GP.

In vitro releasing demonstrated that MS F-CTS-SA-GP retained desirable in vitro sustained-release characteristics as a vaginal delivery system.

Bioadhesion measurement showed that MS-CTS-SA-GP exhibited the highest mucoadhesive strength.

Collectively, MS-CTS-SA-GP holds great promise for topical applications as a sustained-release vaginal drug delivery system.

American Psychological Association (APA)

Yang, Ting-Ting& Cheng, Yuan-Zheng& Qin, Meng& Wang, Yong-Hong& Zhang, Weifen& Wang, An-Lin…[et al.]. 2017. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136078

Modern Language Association (MLA)

Yang, Ting-Ting…[et al.]. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1136078

American Medical Association (AMA)

Yang, Ting-Ting& Cheng, Yuan-Zheng& Qin, Meng& Wang, Yong-Hong& Zhang, Weifen& Wang, An-Lin…[et al.]. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136078

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1136078