Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery
Joint Authors
Zhang, Wei Fen
Zhang, Weifen
Wang, Yong-Hong
Yang, Ting-Ting
Cheng, Yuan-Zheng
Qin, Meng
Wang, An-Lin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages.
However, burst release of drugs is becoming a critical challenge when the hydrogels are employed.
Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation.
Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL).
The physicochemical properties of the optimal MS (MS F) were characterized.
Depending on the gelation temperature and gelating time, the optimal CTS-sodium alginate- (SA-) α,β-glycerophosphate (GP) (CTS-SA-GP) hydrogel was obtained.
Observed by scanning electron microscope (SEM), TFV/BSP/CTS MS were successfully encapsulated in CTS-SA-GP.
In vitro releasing demonstrated that MS F-CTS-SA-GP retained desirable in vitro sustained-release characteristics as a vaginal delivery system.
Bioadhesion measurement showed that MS-CTS-SA-GP exhibited the highest mucoadhesive strength.
Collectively, MS-CTS-SA-GP holds great promise for topical applications as a sustained-release vaginal drug delivery system.
American Psychological Association (APA)
Yang, Ting-Ting& Cheng, Yuan-Zheng& Qin, Meng& Wang, Yong-Hong& Zhang, Weifen& Wang, An-Lin…[et al.]. 2017. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136078
Modern Language Association (MLA)
Yang, Ting-Ting…[et al.]. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1136078
American Medical Association (AMA)
Yang, Ting-Ting& Cheng, Yuan-Zheng& Qin, Meng& Wang, Yong-Hong& Zhang, Weifen& Wang, An-Lin…[et al.]. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136078