The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis
Joint Authors
Huang, Pan
He, Xiao-ying
Xu, Min
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to investigate the expression and significance of miRNA-146a in peripheral blood of patients with carotid atherosclerosis (CAS).
Patients with CAS were selected as the stenosis (CAS) group (n=180).
According to the degree of stenosis, they were divided into the mild stenosis group (MS group, n=64), moderate stenosis group (M group, n=62 cases), and severe stenosis group (SS group, n=54).
According to the plaque type, patients were divided into a stable plaque group (SP group, n=96) and a vulnerable plaque group (VP group, n=84).
Patients without CAS represented the normal group (n=90).
The expression levels of miRNA-146a as well as IL-6 and TNF-α in peripheral blood were detected by RT-PCR and ELISA, respectively.
The expression levels of miRNA-146a, IL-6, and TNF-α in the CAS group were higher than those in the normal group and positively correlated with the degree of stenosis and plaque vulnerability.
The expression levels of miRNA-146a, IL-6, and TNF-α in the stable plaque group were lower than those in the vulnerable plaque group.
The area under the curve of miRNA-146a predicting the vulnerability of plaques was significant at 0.641.
The expression level of miRNA-146a in the CAS group was positively correlated with IL-6 and TNF-α levels.
Our results indicate that miRNA-146a may participate in the occurrence and development of CAS by regulating the expression of IL-6 and TNF-α, which may be potential biomarkers of CAS.
American Psychological Association (APA)
Huang, Pan& He, Xiao-ying& Xu, Min. 2020. The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136080
Modern Language Association (MLA)
Huang, Pan…[et al.]. The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136080
American Medical Association (AMA)
Huang, Pan& He, Xiao-ying& Xu, Min. The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136080