Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method
Joint Authors
Li, Wan-Shu
Wang, Zhe
Huang, Cheng-ke
Chen, Ruimin
Sun, Rui
Hu, Xiaoxia
Chen, Ruijie
Sun, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo.
After pretreatment for 7 days with anlotinib (treatment group) or saline (control group) by oral administration, probe drugs phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam were administered to rats by oral administration.
Blood samples were obtained at a series of time-points and the concentrations of five probe drugs in plasma were determined by a UHPLC-MS/MS method.
The results showed that treatment with anlotinib had no significant effect on rat CYP1A2, CYP2D2, and CYP2C6.
However, anlotinib had a significant inductive effect on CYP2D1 and CYP3A1/2.
Therefore, caution is needed during the concomitant use of anlotinib with other drugs metabolized by CYP2D1 and CYP3A1/2 because of potential drug-anlotinib interactions.
American Psychological Association (APA)
Sun, Wei& Wang, Zhe& Chen, Ruimin& Huang, Cheng-ke& Sun, Rui& Hu, Xiaoxia…[et al.]. 2017. Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136155
Modern Language Association (MLA)
Sun, Wei…[et al.]. Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1136155
American Medical Association (AMA)
Sun, Wei& Wang, Zhe& Chen, Ruimin& Huang, Cheng-ke& Sun, Rui& Hu, Xiaoxia…[et al.]. Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136155