Macrophage Deficiency Makes Intestinal Epithelial Cells Susceptible to NSAID-Induced Damage
Joint Authors
Wu, Di
Guo, Xin
Li, Shuo
Xie, Tianyu
Wang, Jiayang
Lu, Yixun
Chen, Lin
Wang, Xinxin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
In Crohn’s disease (CD), the mechanisms underlying the regulation by granulocyte-macrophage colony-stimulating factor (GM-CSF) of mucosal barrier function in the ileum are unclear.
We analyzed the molecular mechanisms underlying the regulation by GM-CSF of the mucosal barrier function.
Methods.
We examined the role of GM-CSF in the intestinal barrier function in CD at the molecular-, cellular-, and animal-model levels.
Results.
Macrophages directly secreted GM-CSF, promoting intestinal epithelial proliferation and inhibiting apoptosis, which maintained intestinal barrier function.
Macrophages were absent in NSAID-induced ileitis, causing GM-CSF deficiency, increasing the apoptosis rate, decreasing the proliferation rate, increasing inter- and paracellular permeabilities, decreasing the TJP levels, and reducing the numbers of mesenteric lymph nodes, memory T cells, and regulatory T cells in Csf1op/op transgenic mice.
Conclusions.
GM-CSF is required for the maintenance of intestinal barrier function.
Macrophages directly secrete GM-CSF, promoting intestinal epithelial proliferation and inhibiting apoptosis.
American Psychological Association (APA)
Wang, Xinxin& Wang, Jiayang& Xie, Tianyu& Li, Shuo& Wu, Di& Lu, Yixun…[et al.]. 2020. Macrophage Deficiency Makes Intestinal Epithelial Cells Susceptible to NSAID-Induced Damage. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136162
Modern Language Association (MLA)
Wang, Xinxin…[et al.]. Macrophage Deficiency Makes Intestinal Epithelial Cells Susceptible to NSAID-Induced Damage. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136162
American Medical Association (AMA)
Wang, Xinxin& Wang, Jiayang& Xie, Tianyu& Li, Shuo& Wu, Di& Lu, Yixun…[et al.]. Macrophage Deficiency Makes Intestinal Epithelial Cells Susceptible to NSAID-Induced Damage. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136162