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Chronic Venous Disease Patients Showed Altered Expression of IGF-1PAPP-ASTC-2 Axis in the Vein Wall
Joint Authors
Ortega, Miguel A.
Fraile-Martínez, Oscar
Asúnsolo, Ángel
Martínez-Vivero, Clara
Pekarek, Leonel
Coca, Santiago
Guijarro, Luis G.
Álvarez-Mon, Melchor
Buján, Julia
García-Honduvilla, Natalio
Sainz, Felipe
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%.
It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD.
In this regard, it has been described how different axis, such as IGF-1/PAPP-A/STC-2 axis, may play an essential role in tissue homeostasis.
The aim of this research is to study both genetic and protein expressions of the IGF-1/PAPP-A/STC-2 axis in CVeD patients.
It is a cross-sectional study in which genetic (RT-qPCR) and protein (immunohistochemistry) expression analysis techniques were accomplished in saphenous veins from CVeD patients (n=35) in comparison to individuals without vascular pathology (HV).
Results show a significant increase in both genetic and protein expressions of PAPP-A and IGF-1, and a decrement STC-2 expression at the same time in CVeD patients.
Our study is a pioneer for demonstrating that the expression of the different components of the IGF-1/PAPP-A/STC-2 axis is altered in CVeD patients.
This fact can be a part of the loss of homeostatic mechanisms of the venous tissue.
Further research should be destined to deepen into alterations of this axis, as well as to evaluate the usage of these components as therapeutic targets for CVeD.
American Psychological Association (APA)
Ortega, Miguel A.& Fraile-Martínez, Oscar& Asúnsolo, Ángel& Martínez-Vivero, Clara& Pekarek, Leonel& Coca, Santiago…[et al.]. 2020. Chronic Venous Disease Patients Showed Altered Expression of IGF-1PAPP-ASTC-2 Axis in the Vein Wall. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136190
Modern Language Association (MLA)
Ortega, Miguel A.…[et al.]. Chronic Venous Disease Patients Showed Altered Expression of IGF-1PAPP-ASTC-2 Axis in the Vein Wall. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1136190
American Medical Association (AMA)
Ortega, Miguel A.& Fraile-Martínez, Oscar& Asúnsolo, Ángel& Martínez-Vivero, Clara& Pekarek, Leonel& Coca, Santiago…[et al.]. Chronic Venous Disease Patients Showed Altered Expression of IGF-1PAPP-ASTC-2 Axis in the Vein Wall. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136190