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HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
Joint Authors
Sun, Chuanhui
Han, Changsong
Wang, Peng
Jin, Yinji
Sun, Yanan
Qu, Lingmei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of this study was to investigate the HOX gene expression profile in laryngeal squamous cell carcinoma (LSCC) and assess whether some genes are associated with the clinicopathological features and prognosis in LSCC patients.
The HOX gene levels were tested by microarray and validated by qRT-PCR in paired cancerous and adjacent noncancerous LSCC tissue samples.
The microarray testing data of 39 HOX genes revealed 15 HOX genes that were at least 2-fold upregulated and 2 that were downregulated.
After qRT-PCR evaluation, the three most upregulated genes (HOXB9, HOXB13, and HOXD13) were selected for tissue microarray (TMA) analysis.
The correlations between the HOXB9, HOXB13, and HOXD13 expression levels and both clinicopathological features and prognosis were analyzed.
Three HOX gene expression levels were markedly increased in LSCC tissues compared with adjacent noncancerous tissues (P<0.001).
HOXB9 was found to correlate with histological grade (P<0.01) and prognosis (P<0.01) in LSCC.
In conclusion, this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in LSCC.
Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients.
American Psychological Association (APA)
Sun, Chuanhui& Han, Changsong& Wang, Peng& Jin, Yinji& Sun, Yanan& Qu, Lingmei. 2017. HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136203
Modern Language Association (MLA)
Sun, Chuanhui…[et al.]. HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136203
American Medical Association (AMA)
Sun, Chuanhui& Han, Changsong& Wang, Peng& Jin, Yinji& Sun, Yanan& Qu, Lingmei. HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136203