Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection
Joint Authors
Li, Xiangyong
Jie, Yusheng
Chong, Yutian
Gong, Jiao
Xiao, Cuicui
Cao, Jing
Tsia Hin Fong, Christ-Jonathan
Lin, Guoli
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Prediction of HBsAg seroclearance, defined as the loss of circulating HBsAg with or without development of antibodies for HBsAg in patients with chronic hepatitis B (CHB), is highly difficult and challenging due to its low incidence.
This study is aimed at developing and validating a nomogram for prediction of HBsAg loss in CHB patients.
Methods.
We analyzed a total of 1398 patients with CHB.
Two-thirds of the patients were randomly assigned to the training set (n=918), and one-third were assigned to the validation set (n=480).
Univariate and multivariate analysis by Cox regression analysis was performed using the training set, and the nomogram was constructed.
Discrimination and calibration were performed using the training set and validation set.
Results.
On multivariate analysis of the training set, independent factors for HBsAg loss including BMI, HBeAg status, HBsAg titer (quantitative HBsAg), and baseline hepatitis B virus (HBV) DNA level were incorporated into the nomogram.
The HBsAg seroclearance calibration curve showed an optimal agreement between predictions by the nomogram and actual observation.
The concordance index (C-index) of nomogram was 0.913, with confirmation in the validation set where the C-index was 0.886.
Conclusions.
We established and validated a novel nomogram that can individually predict HBsAg seroclearance and non-seroclearance for CHB patients, which is clinically unprecedented.
This practical prognostic model may help clinicians in decision-making and design of clinical studies.
American Psychological Association (APA)
Cao, Jing& Gong, Jiao& Tsia Hin Fong, Christ-Jonathan& Xiao, Cuicui& Lin, Guoli& Li, Xiangyong…[et al.]. 2020. Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136222
Modern Language Association (MLA)
Cao, Jing…[et al.]. Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136222
American Medical Association (AMA)
Cao, Jing& Gong, Jiao& Tsia Hin Fong, Christ-Jonathan& Xiao, Cuicui& Lin, Guoli& Li, Xiangyong…[et al.]. Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136222