Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients
Joint Authors
Bautista, Alexander
Wright, Theodore B.
Meany, Janice
Kandadai, Sunitha K.
Brown, Benjamin
Khalafalla, Kareim
Hashem, Saeed
Smith, Jason W.
Ayyoubi, Tayyeb M.
Dalton, Jarrod E.
Sessler, Daniel I.
Obal, Detlef
Wadhwa, Anupama
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Prolonged storage of packed red blood cells (PRBCs) may increase morbidity and mortality, and patients having massive transfusion might be especially susceptible.
We therefore tested the hypothesis that prolonged storage increases mortality in patients receiving massive transfusion after trauma or nontrauma surgery.
Secondarily, we considered the extent to which storage effects differ for trauma and nontrauma surgery.
Methods.
We considered surgical patients given more than 10 units of PRBC within 24 hours and evaluated the relationship between mean PRBC storage duration and in-hospital mortality using multivariable logistic regression.
Potential nonlinearities in the relationship were assessed via restricted cubic splines.
The secondary hypothesis was evaluated by considering whether there was an interaction between the type of surgery (trauma versus nontrauma) and the effect of storage duration on outcomes.
Results.
305 patients were given a total of 8,046 units of PRBCs, with duration ranging from 8 to 36 days (mean ± SD: 22±6 days).
The odds ratio [95% confidence interval (CI)] for in-hospital mortality corresponding to a one-day in mean PRBC storage duration was 0.99 (0.95, 1.03, P=0.77).
The relationship did not differ for trauma and nontrauma patients (P=0.75).
Results were similar after adjusting for multiple potential confounders.
Conclusions.
Mortality after massive blood transfusion was no worse in patients transfused with PRBC stored for long periods.
Trauma and nontrauma patients did not differ in their susceptibility to prolonged PRBC storage.
American Psychological Association (APA)
Bautista, Alexander& Wright, Theodore B.& Meany, Janice& Kandadai, Sunitha K.& Brown, Benjamin& Khalafalla, Kareim…[et al.]. 2017. Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136290
Modern Language Association (MLA)
Bautista, Alexander…[et al.]. Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1136290
American Medical Association (AMA)
Bautista, Alexander& Wright, Theodore B.& Meany, Janice& Kandadai, Sunitha K.& Brown, Benjamin& Khalafalla, Kareim…[et al.]. Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136290