Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc
Joint Authors
Koch, Timothy R.
Zubowicz, Elizabeth A.
Gross, John B.
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 30-year-old female underwent vertical sleeve gastrectomy.
Postoperatively, hypercupremia and elevated ceruloplasmin were identified.
Further testing revealed normal blood levels of transaminases, alkaline phosphatase, and albumin.
She stopped ingestion of multivitamins, began a copper-free multivitamin, and then began a low copper diet, but with no improvement in hypercupremia.
Protein electrophoresis was normal with no M-spike.
Urinary copper excretion was normal at 0.24 micromol/24 hours (normal: < 0.55), and there were no Kayser-Fleischer rings on slit lamp examination.
Two years postoperatively, she lost 44% of excess preoperative weight and she began zinc sulfate before meals twice daily (115 mg elemental Zinc/day).
At 2 months and 8 months later, plasma copper and ceruloplasmin had essentially normalized.
Increased production of ceruloplasmin could have been a response to significant weight loss or the presence of nonalcoholic steatohepatitis.
The mechanism of zinc’s beneficial effect is uncertain but may be related to suppressing hepatic synthesis of or secretion of ceruloplasmin.
American Psychological Association (APA)
Koch, Timothy R.& Zubowicz, Elizabeth A.& Gross, John B.. 2019. Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc. Case Reports in Gastrointestinal Medicine،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136295
Modern Language Association (MLA)
Koch, Timothy R.…[et al.]. Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc. Case Reports in Gastrointestinal Medicine No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1136295
American Medical Association (AMA)
Koch, Timothy R.& Zubowicz, Elizabeth A.& Gross, John B.. Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc. Case Reports in Gastrointestinal Medicine. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136295