Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice
Joint Authors
Nelson, Victoria L. Boughton
Negrón, Ariel L.
Reid, Inefta
Thomas, Justin A.
Yang, Leon
Lin, Richard Z.
Acosta-Martínez, Maricedes
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Deletion of PI3K catalytic subunit p110α in adipose tissue (aP2-Cre/p110αflx/flx, α−/− hereafter) results in increased adiposity, glucose intolerance, and liver steatosis.
Because this endocrine organ releases hormones like leptin, which are important in reproductive physiology, we investigated the reproductive phenotype of α−/− males.
Compared to controls, α−/− males displayed delayed onset of puberty accompanied by a reduction in plasma LH levels and testicular weight.
At postnatal day 30, α−/− mice exhibited normal body weight but elevated fasted plasma leptin levels.
Testicular leptin gene expression was increased, whereas expression of the cholesterol transporter StAR and of P450 cholesterol side chain cleavage enzyme was decreased.
Adult α−/− males were infertile and exhibited hyperandrogenemia with normal basal LH, FSH, and estradiol levels.
However, neither sperm counts nor sperm motility was different between genotypes.
The mRNA levels of leptin and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult α−/− males.
The mRNA levels of ERα, an important regulator of intratesticular steroidogenesis, were lower in the testis of adult and peripubertal α−/− males.
We propose that chronic hyperleptinemia contributes to the negative impact that disrupting PI3K signaling in adipocytes has on puberty onset, steroidogenesis, and fertility in males.
American Psychological Association (APA)
Nelson, Victoria L. Boughton& Negrón, Ariel L.& Reid, Inefta& Thomas, Justin A.& Yang, Leon& Lin, Richard Z.…[et al.]. 2017. Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136338
Modern Language Association (MLA)
Nelson, Victoria L. Boughton…[et al.]. Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1136338
American Medical Association (AMA)
Nelson, Victoria L. Boughton& Negrón, Ariel L.& Reid, Inefta& Thomas, Justin A.& Yang, Leon& Lin, Richard Z.…[et al.]. Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136338