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First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan
Joint Authors
Chuah, Seng-Kee
Lee, Chen-Hsiang
Yao, Chih-Chien
Tsai, Kai-Lung
Wang, Hsing-Ming
Tsai, Cheng-En
Huang, Chih-Fang
Chiu, Chien-Hua
Chiu, Yi-Chun
Wu, Keng-Liang
Kuo, Chung-Mou
Liang, Chih-Ming
Tai, Wei-Chen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Patients with chronic kidney disease (CKD) and Helicobacter pylori (H.
pylori) infection have a higher incidence of gastroduodenal diseases and therefore are recommended to receive eradication therapies.
This study aimed to assess the efficacy of a 7-day standard triple therapy in patients with CKD (eGFR < 60 ml/min/1.73 m2) and to investigate the clinical factors influencing the success of eradication.
Methods.
A total of 758 patients with H.
pylori infection receiving a 7-day standard first-line triple therapy between January 1, 2013, and December 31, 2014, were recruited.
Patients were divided into two groups: CKD group (N=130) and non-CKD group (N=628).
Results.
The eradication rates attained by the CKD and non-CKD groups were 85.4% and 85.7%, respectively, in the per-protocol analysis (p=0.933).
The eradication rate in CKD stage 3 was 84.5% (82/97), in stage 4 was 88.2% (15/17), and in those who received hemodialysis was 87.5% (14/16).
There were no significant differences in the various stages of CKD (p=0.982).
The adverse events were similar between the two groups (3.1% versus 4.6%, p=0.433).
Compliance between the two groups was good (100.0% versus 99.8%, p=0.649).
There was no significant clinical factor influencing the H.
pylori eradication rate in the non-CKD and CKD groups.
Conclusions.
This study suggests that the H.
pylori eradication rate and adverse rate in patients with CKD are comparable to those of non-CKD patients.
American Psychological Association (APA)
Liang, Chih-Ming& Chiu, Chien-Hua& Wang, Hsing-Ming& Tai, Wei-Chen& Yao, Chih-Chien& Tsai, Cheng-En…[et al.]. 2017. First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136348
Modern Language Association (MLA)
Liang, Chih-Ming…[et al.]. First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1136348
American Medical Association (AMA)
Liang, Chih-Ming& Chiu, Chien-Hua& Wang, Hsing-Ming& Tai, Wei-Chen& Yao, Chih-Chien& Tsai, Cheng-En…[et al.]. First-Line Helicobacter pylori Eradication in Patients with Chronic Kidney Diseases in Taiwan. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136348