Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients
Joint Authors
Shi, Ting
Li, Jiang
Luo, Saiqun
Tan, Chaochao
Wang, Yupeng
Wang, Hongbo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
This study aimed to evaluate the potential effect of hyperhomocysteinemia on multiple organ failure (MOF) in patients with acute pancreatitis (AP).
Method.
In this cohort study, a total of 1880 AP patients were enrolled and divided into the hyperhomocysteinemia group (study group) and the control group based on serum homocysteine (HCY) levels.
Clinical data including demographics, clinical outcomes, and characteristics were collected for analysis.
Risk factors of MOF in AP patients were determined by univariate and multivariate logistic regression analyses.
Results.
The hyperhomocysteinemia group showed higher multiple organ failure rates (31.83% vs 20.77%, P<0.001), compared with the control group.
A positive correlation between homocysteine level and APACHE II score was obtained by Pearson correlation analysis (r = 0.420, P<0.001).
Multivariate logistic regression analysis disclosed that the hyperhomocysteinemia was independently associated with MOF (hazard ratio, 1.103; 95% CI, 1.010–1.189; P=0.012).
Conclusion.
A high serum homocysteine level may be an independent risk factor of multiple organ failure in patients with acute pancreatitis.
American Psychological Association (APA)
Li, Jiang& Luo, Saiqun& Tan, Chaochao& Shi, Ting& Wang, Yupeng& Wang, Hongbo. 2020. Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136370
Modern Language Association (MLA)
Li, Jiang…[et al.]. Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136370
American Medical Association (AMA)
Li, Jiang& Luo, Saiqun& Tan, Chaochao& Shi, Ting& Wang, Yupeng& Wang, Hongbo. Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136370