Role of FGF23 in Pediatric Hypercalciuria
Joint Authors
Moreira Guimarães Penido, Maria Goretti
de Sousa Tavares, Marcelo
Saggie Alon, Uri
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
This study explored the possible role of FGF23 in pediatric hypercalciuria.
Methods.
Plasma FGF23 was measured in 29 controls and 58 children and adolescents with hypercalciuria: 24 before treatment (Pre-Treated) and 34 after 6 months of treatment (Treated).
Hypercalciuric patients also measured serum PTH hormone, 25(OH)vitD, phosphate, calcium, creatinine, and 24 h urine calcium, phosphate, and creatinine.
Results.
There were no differences in age, gender, ethnicity, or body mass index either between controls and patients, or between Pre-Treated and Treated patients.
Median plasma FGF23 in controls was 72 compared with all patients, 58 RU/mL (p=0.0019).
However, whereas FGF23 in Pre-Treated patients, 73 RU/mL, was not different from controls, in Treated patients it was 50 RU/mL, significantly lower than in both controls (p<0.0001) and Pre-Treated patients (p=0.02).
In all patients, there was a correlation between FGF23 and urinary calcium (r=0.325; p=0.0014).
Treated patients had significantly lower urinary calcium (p<0.0001), higher TP/GFR (p<0.001), and higher serum phosphate (p=0.007) versus Pre-Treated patients.
Conclusions.
Pharmacological treatment of hypercalciuric patients resulted in significantly lower urinary calcium excretion, lower serum FGF23, and elevated TP/GFR and serum phosphate concentration, without significant changes in PTH.
Further studies are indicated.
This trial is registered with Clinical Registration Number RBR 8W27X5.
American Psychological Association (APA)
Moreira Guimarães Penido, Maria Goretti& de Sousa Tavares, Marcelo& Saggie Alon, Uri. 2017. Role of FGF23 in Pediatric Hypercalciuria. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136373
Modern Language Association (MLA)
Moreira Guimarães Penido, Maria Goretti…[et al.]. Role of FGF23 in Pediatric Hypercalciuria. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1136373
American Medical Association (AMA)
Moreira Guimarães Penido, Maria Goretti& de Sousa Tavares, Marcelo& Saggie Alon, Uri. Role of FGF23 in Pediatric Hypercalciuria. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136373