Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient

Abstract EN

Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology.

We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11.

The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate.

This case highlights an unusual co-occurrence of hematologic malignancy and chronic ITP in an otherwise healthy child.

We speculate that underlying genetic or immunologic lesions may predispose a subset of pediatric ITP patients to the development of hematologic malignancies.