Use Chou’s 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information
Joint Authors
Ding, Yijie
Lu, Weizhong
Song, Zhengwei
Wu, Hongjie
Cao, Yan
Zhang, Yu
Li, Haiou
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The knowledge of DNA-binding proteins would help to understand the functions of proteins better in cellular biological processes.
Research on the prediction of DNA-binding proteins can promote the research of drug proteins and computer acidified drugs.
In recent years, methods based on machine learning are usually used to predict proteins.
Although great predicted performance can be achieved via current methods, researchers still need to invest more research in terms of the improvement of predicted performance.
In this study, the prediction of DNA-binding proteins is studied from the perspective of evolutionary information and the support vector machine method.
One machine learning model for predicting DNA-binding proteins based on evolutionary features by using Chou’s 5-step rule is put forward.
The results show that great predicted performance is obtained on benchmark dataset PDB1075 and independent dataset PDB186, achieving the accuracy of 86.05% and 75.30%, respectively.
Thus, the method proposed is comparable to a certain degree, and it may work even better than other methods to some extent.
American Psychological Association (APA)
Lu, Weizhong& Song, Zhengwei& Ding, Yijie& Wu, Hongjie& Cao, Yan& Zhang, Yu…[et al.]. 2020. Use Chou’s 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136402
Modern Language Association (MLA)
Lu, Weizhong…[et al.]. Use Chou’s 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136402
American Medical Association (AMA)
Lu, Weizhong& Song, Zhengwei& Ding, Yijie& Wu, Hongjie& Cao, Yan& Zhang, Yu…[et al.]. Use Chou’s 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136402