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The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure
Joint Authors
Bogomolovas, Julius
Bironaitė, Daiva
Grabauskienė, Virginija
Baltrūnienė, Vaida
Kažukauskienė, Ieva
Vitkus, Dalius
Ručinskas, Kęstutis
Žurauskas, Edvardas
Augulis, Renaldas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Clinical interpretation of patients’ plasma adiponectin (APN) remains challenging; its value as biomarker in dilated cardiomyopathy (DCM) is equivocal.
We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD) implantation, and heart transplantation (HT) in patients with nonischemic DCM.
57 patients with nonischemic DCM (average LV diastolic diameter 6.85 cm, LV ejection fraction 26.63%, and pulmonary capillary wedge pressure 22.06 mmHg) were enrolled.
Patients underwent echocardiography, right heart catheterization, and endomyocardial biopsy.
During a mean follow-up of 33.42 months, 15 (26%) patients died, 12 (21%) patients underwent HT, and 8 (14%) patients were implanted with LVAD.
APN level was significantly higher in patients who experienced study endpoints (23.4 versus 10.9 ug/ml, p=0.01).
APN was associated with worse outcome in univariate Cox proportional hazards model (HR 1.04, CI 1.02–1.07, p=0.001) but lost significance adjusting for other covariates.
Average global strain (AGS) is an independent outcome predictor (HR 1.42, CI 1.081–1.866, p=0.012).
Increased circulating APN level was associated with higher mortality and may be an additive prognostic marker in DCM with advanced HF.
Combination of serum (APN, BNP, TNF-α) and echocardiographic (AGS) markers may increase the HF predicting power for the nonischemic DCM patients.
American Psychological Association (APA)
Baltrūnienė, Vaida& Bironaitė, Daiva& Kažukauskienė, Ieva& Bogomolovas, Julius& Vitkus, Dalius& Ručinskas, Kęstutis…[et al.]. 2017. The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136426
Modern Language Association (MLA)
Baltrūnienė, Vaida…[et al.]. The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1136426
American Medical Association (AMA)
Baltrūnienė, Vaida& Bironaitė, Daiva& Kažukauskienė, Ieva& Bogomolovas, Julius& Vitkus, Dalius& Ručinskas, Kęstutis…[et al.]. The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136426