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Downregulation of CyclophilinACD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness
Joint Authors
Xu, Shengchao
Hu, Chi
Xiao, Zhiqiang
Luo, Chengke
Liu, Zhixiong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gliomas are the most common primary tumors in the brain with poor prognosis.
Previous studies have detected high expression of Cyclophilin A (CyPA) and CD147, respectively, in glioma.
However, the correlation between their expressions and glioma prognosis remains unclear.
Here, we investigated the expression of CyPA and CD147 in different types of glioma and characterized their relationships with clinical features, prognosis, and cell proliferation.
Results showed that CyPA and CD147 expressions were elevated in higher grade gliomas.
Moreover, the knockdown of CyPA and CD147 by RNA interference significantly induced cell express apoptosis biomarkers such as Annexin V and inhibited proliferation biomarkers like EdU in glioma cells.
In summary, our findings revealed that high expression of CyPA and CD147 correlated with glioma grades.
Moreover, downregulation of the Cyclophilin A/CD147 axis induces cell apoptosis and inhibits glioma aggressiveness.
Those indicating CyPA and CD147 could be used as both potential predictive biomarkers and a potential therapeutic target.
American Psychological Association (APA)
Xu, Shengchao& Hu, Chi& Xiao, Zhiqiang& Luo, Chengke& Liu, Zhixiong. 2020. Downregulation of CyclophilinACD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136430
Modern Language Association (MLA)
Xu, Shengchao…[et al.]. Downregulation of CyclophilinACD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136430
American Medical Association (AMA)
Xu, Shengchao& Hu, Chi& Xiao, Zhiqiang& Luo, Chengke& Liu, Zhixiong. Downregulation of CyclophilinACD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136430