Prevalence and Antifungal Susceptibility Profile of Clinically Relevant Candida Species in Postmenopausal Women with Diabetes
Joint Authors
Awad, Mohamed
Al Halteet, Sarah
Abdel-Hadi, Ahmed
Hassan, Mohamed
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence of diabetes mellitus has increased in Saudi Arabia, which has raised the risk of vulvovaginal candidiasis (VVC).
This study highlights the prevalence and antifungal susceptibility of Candida species among postmenopausal women with diabetes with symptoms of VVC in Taif, a city in Saudi Arabia.
Several diagnostic tools were used to differentiate the yeast isolates, including microscopic examination, culture morphology on CHROM agar, further confirmation with the VITEK 2 system, and ITS1 and ITS4 region sequencing.
Antifungal susceptibility of the selected Candida species was determined using the VITEK 2 system (bioMérieux Inc., USA).
Out of the 550 high vaginal swabs investigated, 86 specimens were Candida species positive (15.6%) with a significant difference according to age; the positivity in the 45–50 years’ age group (12%) was higher than that in the 51–55 years’ age group (3.6%).
Candida albicans was the most common causative agent in 51 samples (59.3%), followed by C.
glabrata in 21 samples (24.41%) and C.
krusei in 14 samples (16.27%), with no significant differences between the age groups.
Three isolates, including two C.
albicans and one C.
krusei, exhibited resistance against all the tested antifungal agents.
CHROM agar and VITEK 2 were accurate phenotypic tools to identify Candida species with 100% sensitivity and specificity and were consistent with the phylogenetic characterization.
The data emphasized the importance of identifying Candida species and their antifungal susceptibility among postmenopausal women with diabetes, highlighting the potential risk posed by diabetes in this age group.
American Psychological Association (APA)
Al Halteet, Sarah& Abdel-Hadi, Ahmed& Hassan, Mohamed& Awad, Mohamed. 2020. Prevalence and Antifungal Susceptibility Profile of Clinically Relevant Candida Species in Postmenopausal Women with Diabetes. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136437
Modern Language Association (MLA)
Al Halteet, Sarah…[et al.]. Prevalence and Antifungal Susceptibility Profile of Clinically Relevant Candida Species in Postmenopausal Women with Diabetes. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136437
American Medical Association (AMA)
Al Halteet, Sarah& Abdel-Hadi, Ahmed& Hassan, Mohamed& Awad, Mohamed. Prevalence and Antifungal Susceptibility Profile of Clinically Relevant Candida Species in Postmenopausal Women with Diabetes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136437