Prolonged Remission of Cancer of Unknown Primary following Initiation of Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
Joint Authors
Lim, Ming Y.
Volmar, Keith E.
Key, Nigel S.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report the case of a 64-year-old woman who presented with cancer of unknown primary treated with carboplatin and paclitaxel, followed by maintenance erlotinib.
Her chemotherapy regimen was discontinued due to the development of profound hemolysis that was later identified to be due to paroxysmal nocturnal hemoglobinuria (PNH).
She was started on a complement inhibitory antibody, eculizumab 900 mg every 2 weeks, with marked suppression of hemolysis.
Eight years after diagnosis of cancer, the patient remains on eculizumab with no signs of cancer recurrence on regular imaging.
Regardless of whether the co-occurrence of cancer and PNH was any more than coincidental in this patient, the uniqueness of the case is emphasized by the remarkable and sustained response of not only PNH but also possibly the associated cancer to eculizumab.
American Psychological Association (APA)
Lim, Ming Y.& Volmar, Keith E.& Key, Nigel S.. 2019. Prolonged Remission of Cancer of Unknown Primary following Initiation of Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136467
Modern Language Association (MLA)
Lim, Ming Y.…[et al.]. Prolonged Remission of Cancer of Unknown Primary following Initiation of Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria. Case Reports in Hematology No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1136467
American Medical Association (AMA)
Lim, Ming Y.& Volmar, Keith E.& Key, Nigel S.. Prolonged Remission of Cancer of Unknown Primary following Initiation of Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136467