Efficacy of probiotic (Protoxine) on mercury-induced nephrotoxicity and lipid peroxidation in rats
Other Title(s)
تأثير إعطاء المسكن الحيوي (البروتوكسين) في تسمم و أكسدة الدهون في كلى الجرذان المعاملة بالزئبق
Joint Authors
al-Sumaydi, Ajwad Awwad Muhammad
al-Nuaymi, Nathirah Muhammad Ali
al-Qutubi, Suhir Hasan
Fadil, Ammar Amir
Source
Publisher
University of Diyala College of Agriculture
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
- Oxidative Stress
- Enzymes
- Histopathology changes
- Lipid peroxidation
- Mercuric chloride
- Superoxide dismutase
English Abstract
Mercury is the third most dangerous heavy metal and its toxicity causes serious risks to health through unfavorable pathological and biochemical effects of oxidative stress.
The aim of the present study was to elucidate the possible protective role of protoxine, a probiotic, on mercuric chloride-induced oxidative stress and histopathological changes in the kidneys of the experimented rats.
Adult male Wistar albino rats were daily exposed to mercuric chloride (0.25 mg kg-1) in the diet and water together for 20 days.
Treatment with mercuric chloride led to oxidative stress by elevating malondialdehyde (MDA) level and also decreasing superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities.
Furthermore, mercuric chloride exposure induced histopathological changes characterized by tubulonecrosis in the renal tissue of intoxicated rats.
MDA level, SOD, GSH-Px activities and histopathological changes were modulated in concomitantly daily supplementation of protoxine (12 mg rat-1) to mercuric chloride-treated groups.
Results from current study suggested mercuric chloride treatment resulted lipid peroxidation, alterations of enzymatic antioxidant defense system and histolopathological changes in the kidneys of male rats.
The administration of protoxine proved to be beneficial in ameliorating the mercuric chloride-induced nephrotoxicity.
Data Type
Conference Papers
Record ID
BIM-1136513
American Psychological Association (APA)
al-Sumaydi, Ajwad Awwad Muhammad& al-Nuaymi, Nathirah Muhammad Ali& al-Qutubi, Suhir Hasan& Fadil, Ammar Amir. 2018-12-31. Efficacy of probiotic (Protoxine) on mercury-induced nephrotoxicity and lipid peroxidation in rats. . Vol. 10, Special issue (2018), pp.114-126.ديالى، العراق : جامعة ديالى، كلية الزراعة،.
https://search.emarefa.net/detail/BIM-1136513
Modern Language Association (MLA)
al-Sumaydi, Ajwad Awwad Muhammad…[et al.]. Efficacy of probiotic (Protoxine) on mercury-induced nephrotoxicity and lipid peroxidation in rats. . ديالى، العراق : جامعة ديالى، كلية الزراعة،. 2018-12-31.
https://search.emarefa.net/detail/BIM-1136513
American Medical Association (AMA)
al-Sumaydi, Ajwad Awwad Muhammad& al-Nuaymi, Nathirah Muhammad Ali& al-Qutubi, Suhir Hasan& Fadil, Ammar Amir. Efficacy of probiotic (Protoxine) on mercury-induced nephrotoxicity and lipid peroxidation in rats. .
https://search.emarefa.net/detail/BIM-1136513