Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens
Joint Authors
Sun, Wei
Wu, Xinjie
Tan, Mingsheng
Geng, Chuanying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To investigate the incidence and risk factors for osteonecrosis of femoral head (ONFH) in multiple myeloma (MM) patients undergoing dexamethasone-based regimens (DBRs).
Methods.
A retrospective study was conducted in MM patients administered DBRs between December 2012 and April 2015.
Demographic, clinical, and laboratory data were extracted to compare between two groups.
Incidence of ONFH were calculated and risk factors identified by both univariate and multivariate analysis.
Results.
The study group comprised 105 patients undergoing DBRs.
Seven patients with ONFH after DBRs were classified as the ONFH group, and the other 98 patients without ONFH were included in the non-ONFH group.
Incidence of ONFH was 6.7%.
Median age of developing ONFH was 51 years (45–64), and the male to female ratio was 6 : 1.
A total of 12 femoral heads were involved, including unilateral in 2 patients and bilateral in 5 patients.
After the multivariate analysis, four risk factors were confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia.
Conclusion.
The overall incidence of ONFH in MM patients treated with DBRs is 6.7%, and 4 risk factors are confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia in our study.
American Psychological Association (APA)
Wu, Xinjie& Geng, Chuanying& Sun, Wei& Tan, Mingsheng. 2020. Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136527
Modern Language Association (MLA)
Wu, Xinjie…[et al.]. Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136527
American Medical Association (AMA)
Wu, Xinjie& Geng, Chuanying& Sun, Wei& Tan, Mingsheng. Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136527