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Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship
Joint Authors
Poon, Simon
Sze, Daniel Man-yuen
Ng, Michelle Chun-har
Lau, Tsui-yan
Xu, Qing-song
Lam, Mary K.
Chau, Foo-tim
Fan, Kei
Poon, Josiah
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The current use of a single chemical component as the representative quality control marker of herbal food supplement is inadequate.
In this CD80-Quantitative-Pattern-Activity-Relationship (QPAR) study, we built a bioactivity predictive model that can be applicable for complex mixtures.
Through integrating the chemical fingerprinting profiles of the immunomodulating herb Radix Astragali (RA) extracts, and their related biological data of immunological marker CD80 expression on dendritic cells, a chemometric model using the Elastic Net Partial Least Square (EN-PLS) algorithm was established.
The EN-PLS algorithm increased the biological predictive capability with lower value of RMSEP (11.66) and higher values of Rp2 (0.55) when compared to the standard PLS model.
This CD80-QPAR platform provides a useful predictive model for unknown RA extract’s bioactivities using the chemical fingerprint inputs.
Furthermore, this bioactivity prediction platform facilitates identification of key bioactivity-related chemical components within complex mixtures for future drug discovery and understanding of the batch-to-batch consistency for quality clinical trials.
American Psychological Association (APA)
Ng, Michelle Chun-har& Lau, Tsui-yan& Fan, Kei& Xu, Qing-song& Poon, Josiah& Poon, Simon…[et al.]. 2017. Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136554
Modern Language Association (MLA)
Ng, Michelle Chun-har…[et al.]. Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1136554
American Medical Association (AMA)
Ng, Michelle Chun-har& Lau, Tsui-yan& Fan, Kei& Xu, Qing-song& Poon, Josiah& Poon, Simon…[et al.]. Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136554