Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
Joint Authors
Hair, Pamela S.
Feagin, Lisa M.
Chicella, Michael F.
Kaszowski, Cortney L.
Price, Jessica
Owen, William C.
Cunnion, Kenji M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis.
After chemotherapy, she became febrile and received ceftriaxone.
She rapidly developed respiratory failure and anemia.
Her direct antiglobulin test was positive for IgG and C3.
To confirm this was ceftriaxone-induced complement-mediated hemolysis, we adapted the complement hemolysis using human erythrocytes (CHUHE) assay by adding exogenous ceftriaxone to the patient’s serum which enhanced lysis of her erythrocytes.
We confirmed that ceftriaxone initiated a classical complement pathway-mediated hemolysis by in vitro reversal with peptide inhibitor of complement C1 (PIC1).
American Psychological Association (APA)
Cunnion, Kenji M.& Feagin, Lisa M.& Chicella, Michael F.& Kaszowski, Cortney L.& Hair, Pamela S.& Price, Jessica…[et al.]. 2019. Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1). Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136558
Modern Language Association (MLA)
Cunnion, Kenji M.…[et al.]. Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1). Case Reports in Hematology No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1136558
American Medical Association (AMA)
Cunnion, Kenji M.& Feagin, Lisa M.& Chicella, Michael F.& Kaszowski, Cortney L.& Hair, Pamela S.& Price, Jessica…[et al.]. Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1). Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136558
