Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia
Joint Authors
Feldman, Mark
Yohannan, Binoy
Luu, Dai Chu N.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Drug-associated thrombocytopenia is often unrecognized.
We report a 76-year-old female with lymphoma who presented with easy bruising and oral bleeding.
She had undergone screening for hepatitis B virus (HBV) prior to starting rituximab and was found to have hepatitis B core serum antibody (IgG anti-HBc).
She was therefore treated with prophylactic entecavir 0.5 mg daily to prevent reactivation of HBV.
Her initial platelet count was 136,000/mm3.
Five days after starting entecavir, she presented with bruising and oral bleeding and was found to have a platelet count of 7,000/mm3.
A coagulation profile and the rest of the blood parameters (RBC and WBC counts) were normal.
Entecavir was stopped, and she was given 3 units of apheresed platelets followed by intravenous immunoglobulin (1 g/kg) for 5 consecutive days.
Her platelet counts improved and normalized in one week.
She was diagnosed with entecavir-induced thrombocytopenia based on the temporal relationship and after carefully excluding alternate causes of thrombocytopenia.
This case highlights the importance of recognizing drug-induced thrombocytopenia (DITP) as a reversible cause of thrombocytopenia.
American Psychological Association (APA)
Yohannan, Binoy& Luu, Dai Chu N.& Feldman, Mark. 2019. Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136567
Modern Language Association (MLA)
Yohannan, Binoy…[et al.]. Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia. Case Reports in Hematology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1136567
American Medical Association (AMA)
Yohannan, Binoy& Luu, Dai Chu N.& Feldman, Mark. Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136567