Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos
Joint Authors
García-Chapa, Eiralí Guadalupe
Leal-Ugarte, Evelia
Peralta-Leal, Valeria
Durán-González, Jorge
Meza-Espinoza, Juan Pablo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There are currently about 415 million people with diabetes worldwide, a figure likely to increase to 642 million by 2040.
In 2015, Mexico was the second Latin American country and sixth in the world in prevalence of this disorder with nearly 11.5 million of patients.
Type 2 diabetes (T2D) is the main kind of diabetes and its etiology is complex with environmental and genetic factors involved.
Indeed, polymorphisms in several genes have been associated with this disease worldwide.
To estimate the genetic epidemiology of T2D in Mexican mestizos a systematic bibliographic search of published articles through PubMed, Scopus, Google Scholar, and Web of Science was conducted.
Just case-control studies of candidate genes about T2D in Mexican mestizo inhabitants were included.
Nineteen studies that met the inclusion criteria were found.
In total, 68 polymorphisms of 41 genes were assessed; 26 of them were associated with T2D risk, which were located in ABCA1, ADRB3, CAPN10, CDC123/CAMK1D, CDKAL1, CDKN2A/2B, CRP, ELMO1, FTO, HHEX, IGF2BP2, IRS1, JAZF1, KCNQ1, LOC387761, LTA, NXPH1, SIRT1, SLC30A8, TCF7L2, and TNF-α genes.
Overall, 21 of the 41 analyzed genes were associated with T2D in Mexican mestizos.
Such a genetic heterogeneity compares with findings in other ethnic groups.
American Psychological Association (APA)
García-Chapa, Eiralí Guadalupe& Leal-Ugarte, Evelia& Peralta-Leal, Valeria& Durán-González, Jorge& Meza-Espinoza, Juan Pablo. 2017. Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136582
Modern Language Association (MLA)
García-Chapa, Eiralí Guadalupe…[et al.]. Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136582
American Medical Association (AMA)
García-Chapa, Eiralí Guadalupe& Leal-Ugarte, Evelia& Peralta-Leal, Valeria& Durán-González, Jorge& Meza-Espinoza, Juan Pablo. Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136582