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HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient
Joint Authors
Guerrero, Carlo
Jain, Tania
Kelemen, Katalin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus, is a DNA oncovirus known for its role in the development of Kaposi’s sarcoma (KS) and several lymphoproliferative disorders (LPDs).
HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor signaling pathway, as well as a host of other regulatory mechanisms.
The spectrum of HHV-8-associated LPDs is increasing.
The World Health Organization has recently updated the classification of HHV-8-associated LPDs by introducing HHV-8-positive germinotropic LPD (GLPD) in addition to the previously recognized entities of HHV-8-positive diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), primary effusion lymphoma (PEL), and HHV-8-positive multicentric Castleman’s disease (MCD).
We present here a case of an HIV-positive woman with a history of KS, who later developed three HHV-8-associated LPDs, including HHV-8-positive MCD, PEL, and GLPD.
To the best of our knowledge, this is the first reported case of a patient with this combination of individually rare HHV-8-associated LPDs.
This case illustrates the spectrum and the sequential development of the different clinical manifestations of HHV-8-associated diseases.
Detection of HHV-8 can have clinical significance in the diagnosis and management of certain HHV-8-associated conditions.
Recently discovered variants of HHV-8-associated LPDs indicate that this group represents a diverse spectrum of disorders, whose classification may require further refinement beyond the currently recognized entities.
American Psychological Association (APA)
Guerrero, Carlo& Jain, Tania& Kelemen, Katalin. 2019. HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1136584
Modern Language Association (MLA)
Guerrero, Carlo…[et al.]. HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient. Case Reports in Hematology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1136584
American Medical Association (AMA)
Guerrero, Carlo& Jain, Tania& Kelemen, Katalin. HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1136584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136584