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Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis
Joint Authors
Kou, Jianqiang
Liu, Guoming
Liu, Xiangyun
Li, Tianmi
Wei, Ying
Sun, Yuanliang
Wang, Ting
Wang, Yingzhen
Zheng, Xiujun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recent studies have reported that circular RNAs (circRNAs) play a crucial regulatory role in a variety of human diseases.
However, the roles of circRNAs in ankylosing spondylitis (AS) remain unclear.
In this study, we conducted circRNA expression profiling of the spinal ligament tissues of patients with AS by RNA sequencing (RNA-seq) and analyzed the potential functions of differentially expressed circRNA by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to investigate the potential mechanisms associated with AS.
The results showed that a total of 1,172 circRNAs were detected in the spinal ligament tissue samples, of which 123 circRNAs were significantly differentially expressed by a fold change≥1.5 and p value < 0.05.
Among these, 57 circRNAs were upregulated, and 66 were downregulated.
GO and KEGG analyses demonstrated that the differentially expressed circRNAs were mainly involved in the regulation of biological processes of peptidyl-serine phosphorylation and human immune system that may be related to AS.
In addition, the circRNA/miRNA interaction networks were established to predict the potential roles of differentially expressed circRNAs by bioinformatics analysis.
Taken together, these results revealed the expression profiles of circRNAs and the potential functions of the differentially expressed circRNAs in the spinal ligament tissue of patients with AS, which may provide new clues for understanding the mechanisms associated with AS, and proceed to identify novel potential molecular targets for the diagnoses and treatment of AS.
American Psychological Association (APA)
Kou, Jianqiang& Liu, Guoming& Liu, Xiangyun& Li, Tianmi& Wei, Ying& Sun, Yuanliang…[et al.]. 2020. Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136605
Modern Language Association (MLA)
Kou, Jianqiang…[et al.]. Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1136605
American Medical Association (AMA)
Kou, Jianqiang& Liu, Guoming& Liu, Xiangyun& Li, Tianmi& Wei, Ying& Sun, Yuanliang…[et al.]. Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136605