Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage
Joint Authors
Nagaharu, Keiki
Masuya, Masahiro
Kawakami, Keiki
Katayama, Naoyuki
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Immune thrombocytopenic purpura (ITP) typically presents with bleeding due to immunologic thrombocytopenia.
Severe hemorrhage due to ITP is sometimes lethal, and the urgent recovery of platelets is necessary.
In addition to conventional therapeutic strategies, romiplostim shows promising efficacy for chronic ITP.
However, there is little evidence for the utilization of this treatment for acute ITP or acute exacerbation of chronic ITP.
We report the case details of three elderly ITP patients presenting with lethal diffuse alveolar hemorrhage.
These patients had the following underlying pulmonary diseases: case 1, nontuberculous mycobacterial infection and sarcoidosis; case 2, cryptogenic organizing pneumonia; case 3, pulmonary emphysema.
These patients recovered following treatment with romiplostim at a higher dose (10 μg/kg), in addition to conventional therapies including corticosteroids and high-dose intravenous immunoglobulin.
In summary, the addition of romiplostim resulted in earlier recovery of thrombocytopenia than has been previously reported.
Our three cases suggest that early romiplostim at a higher dose could be an efficacious therapeutic option for acute ITP patients with severe lethal bleeding.
American Psychological Association (APA)
Nagaharu, Keiki& Masuya, Masahiro& Kawakami, Keiki& Katayama, Naoyuki. 2019. Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136617
Modern Language Association (MLA)
Nagaharu, Keiki…[et al.]. Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. Case Reports in Hematology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1136617
American Medical Association (AMA)
Nagaharu, Keiki& Masuya, Masahiro& Kawakami, Keiki& Katayama, Naoyuki. Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136617