Tuberculosis Treatment Outcomes and Factors Associated with Each of Them in a Cohort Followed Up between 2010 and 2014

Joint Authors

Cavalcanti Rolla, Valeria
Schmaltz, Carolina A. S.
Cardoso, Mayara A.
Brasil, Pedro Emmanuel A. A. do
Sant’Anna, Flavia M.

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Tuberculosis treatment has undergone recent changes in Brazil.

Objective.

To assess whether favorable outcomes on tuberculosis therapy improved in recent years.

Methods.

Retrospective observational study, based on primary data of tuberculosis patients, followed at INI-FIOCRUZ, from January 2012 to December 2014.

Results.

The outcomes observed were as follows: cure (80%), default (14%), treatment failure (5%), and death (1%).

HIV infection without antiretroviral therapy [OR 0.34 (0.15–0.79)], tuberculosis diagnosis based on sputum smear [OR 0.22 (0.07–0.74)], drug use [OR 0.22 (0.11–0.46)], and/or treatment interruption due to adverse reactions [OR 0.23 (0.08–0.67)] decreased the chance of cure.

Predictors of default, that is, use of noninjecting drugs [OR 3.00 (95% CL 1.31–6.88)], treatment interruption due to adverse reactions [OR 6.30 (1.81–21.95)], low schooling [OR 2.59 (2.15–5.82)], higher age [OR 0.44 (0.23–0.82)], and female gender [OR 0.28 (0.11–0.71)], reduced the chance of treatment default.

Tuberculosis diagnosis based on sputum smear [OR 7.77 (1.94–31.09)] and/or arterial hypertension [OR 4.07 (1.25–13.18)] was associated with treatment failure.

Conclusion.

Mortality and default were low considering the prevalence of HIV infection; however cure was not significantly increased.

American Psychological Association (APA)

Cardoso, Mayara A.& Brasil, Pedro Emmanuel A. A. do& Schmaltz, Carolina A. S.& Sant’Anna, Flavia M.& Cavalcanti Rolla, Valeria. 2017. Tuberculosis Treatment Outcomes and Factors Associated with Each of Them in a Cohort Followed Up between 2010 and 2014. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136624

Modern Language Association (MLA)

Cardoso, Mayara A.…[et al.]. Tuberculosis Treatment Outcomes and Factors Associated with Each of Them in a Cohort Followed Up between 2010 and 2014. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1136624

American Medical Association (AMA)

Cardoso, Mayara A.& Brasil, Pedro Emmanuel A. A. do& Schmaltz, Carolina A. S.& Sant’Anna, Flavia M.& Cavalcanti Rolla, Valeria. Tuberculosis Treatment Outcomes and Factors Associated with Each of Them in a Cohort Followed Up between 2010 and 2014. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136624

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1136624