An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase
Joint Authors
Kartthik, S.
Mandal, Prakas K.
Abdullah, Saleh Mohammed
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by dysregulated and uncontrolled proliferation of mature and maturing granulocytes with normal differentiation.
A genetic hallmark of CML is the presence of the fusion gene product BCR-ABL.
Bleeding diathesis in CML patients is rare (<10%) and primarily caused by acquired platelet dysfunction.
We report a rare case of an adult CML chronic phase patient who presented with spontaneous muscle hematoma due to acquired Glanzmann’s thrombasthenia (GT).
On laboratory workup, a GT was confirmed along with the diagnosis of CML in chronic phase.
The muscle hematoma was completely resolved following imatinib therapy.
The present case demonstrates that bleeding is a complication of MPNs and highlights the importance of both acquired GT diagnosis to determine the cause of bleeding in CML and of prompt treatment with imatinib to reverse this condition.
American Psychological Association (APA)
Kartthik, S.& Mandal, Prakas K.& Abdullah, Saleh Mohammed. 2019. An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136628
Modern Language Association (MLA)
Kartthik, S.…[et al.]. An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase. Case Reports in Hematology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1136628
American Medical Association (AMA)
Kartthik, S.& Mandal, Prakas K.& Abdullah, Saleh Mohammed. An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136628