Primary versus Redo Urethroplasty: Results from a Single-Center Comparative Analysis
Joint Authors
Oosterlinck, W. J.
Spinoit, A. F.
Palminteri, Enzo
Verla, W.
Waterloos, Marjan
Buelens, Sarah
De Bleser, Elise
Ploumidis, Achilles
Martins, Francisco E.
Lumen, Nicolaas
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To explore the differences between primary and redo urethroplasty and to directly compare according stricture-free survival (SFS).
Materials and Methods.
Data of all male patients who underwent urethroplasty at Ghent University Hospital were collected between 2000 and 2018.
Exclusion criteria for this analysis were age <18 years and follow-up <1 year.
Two patient groups were created for further comparison: the primary urethroplasty (PU) group (no previous urethroplasty) and redo urethroplasty (RU) group (≥1 previous urethroplasty), irrespective of prior endoscopic treatments.
A comparison between groups was performed using the Mann–Whitney U test and Fisher’s Exact test.
SFS was calculated using Kaplan–Meier statistics.
A functional definition of failure, being the need for further urethral manipulation, was used.
Uni- and multivariate Cox regression analyses were performed on the entire patient cohort.
Results.
805 patients were included.
Median (IQR) follow-up of the PU (n = 556) and RU (n = 249) groups was 87 (50–136) and 76 (40–133) months, respectively (p=0.1).
The RU group involved more penile strictures (p<0.001), Lichen Sclerosus (p=0.016), failed hypospadias repair (p=0.004), multistage procedures (p<0.001), and definitive perineostomies (p=0.001).
The 5- and estimated 10-year SFS was, respectively, 86% and 79% for the PU group and, respectively, 75% and 63% for the RU group (p<0.001).
Prior urethroplasty (HR: 1.52; p=0.01) and diabetes (HR: 1.83; p=0.03) remained statistically significant in the multivariate Cox regression analysis.
Conclusions.
Several differences between primary and redo urethroplasties exist.
Redo urethroplasty entails a distinct patient population to treat and is, in general, associated with lower stricture-free survival than primary urethroplasty, although more homogeneous series are required to corroborate these results.
Prior urethroplasty and diabetes are independent risk factors for urethroplasty failure.
American Psychological Association (APA)
Verla, W.& Waterloos, Marjan& Spinoit, A. F.& Buelens, Sarah& De Bleser, Elise& Oosterlinck, W. J.…[et al.]. 2020. Primary versus Redo Urethroplasty: Results from a Single-Center Comparative Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136651
Modern Language Association (MLA)
Verla, W.…[et al.]. Primary versus Redo Urethroplasty: Results from a Single-Center Comparative Analysis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136651
American Medical Association (AMA)
Verla, W.& Waterloos, Marjan& Spinoit, A. F.& Buelens, Sarah& De Bleser, Elise& Oosterlinck, W. J.…[et al.]. Primary versus Redo Urethroplasty: Results from a Single-Center Comparative Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136651