Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol
Joint Authors
Yang, Ming Hui
Lin, Po-Chiao
Chen, Ko-Chin
Chen, Wan-Jou
Chen, Shih-Cheng
Jhuang, Ting-Syuan
Yang, Jean-Dean
Huang, Ying Fong
Jong, Shiang-Bin
Tsai, Wan-Chi
Chung, Tze Wen
Tyan, Yu Chang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility.
In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification.
In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL.
We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles.
The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions.
In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
American Psychological Association (APA)
Chen, Shih-Cheng& Yang, Ming Hui& Chung, Tze Wen& Jhuang, Ting-Syuan& Yang, Jean-Dean& Chen, Ko-Chin…[et al.]. 2017. Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136670
Modern Language Association (MLA)
Chen, Shih-Cheng…[et al.]. Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136670
American Medical Association (AMA)
Chen, Shih-Cheng& Yang, Ming Hui& Chung, Tze Wen& Jhuang, Ting-Syuan& Yang, Jean-Dean& Chen, Ko-Chin…[et al.]. Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136670