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Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma
Joint Authors
Auge, H.
Yguel, C.
Schmitt, E.
Frotscher, B.
Busby-Venner, H.
Morizot, R.
Moulin, C.
Feugier, P.
Perrot, A.
Filliatre-Clement, L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Here, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma.
The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS.
Diagnosis was made based on a stereotaxic intracerebral biopsy.
During this biopsy, a ventriculoperitoneal shunt was established, which was complicated with abnormal bleeding.
Subsequent hemostasis assessment related to hemopathy revealed acquired von Willebrand disease.
The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide.
Our patient currently remains in very good partial response without neurological symptoms after 4 months of maintenance.
The patient is free of progression 14 months after their original presentation.
American Psychological Association (APA)
Auge, H.& Yguel, C.& Schmitt, E.& Frotscher, B.& Busby-Venner, H.& Morizot, R.…[et al.]. 2019. Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136676
Modern Language Association (MLA)
Auge, H.…[et al.]. Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma. Case Reports in Hematology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1136676
American Medical Association (AMA)
Auge, H.& Yguel, C.& Schmitt, E.& Frotscher, B.& Busby-Venner, H.& Morizot, R.…[et al.]. Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1136676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136676