Ductal Carcinoma In Situ of the Breast: Perspectives on Tumor Subtype and Treatment
Joint Authors
Shou, Kangquan
Liu, Yufei
Li, Juanjuan
Wu, Qi
Hu, Yuchang
Wang, Junjie
Cao, Chunyu
Wang, Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate ductal carcinoma in situ (DCIS) characteristics and the effect of different treatment strategies.
Patients and Methods.
Using data with known hormone receptor (HoR) and human epidermal growth factor receptor 2 (HER2) status obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2014, the study was conducted to investigate tumor subtype-specific differences in various characteristics, overall survival (OS), and breast cancer-specific mortality (BCSM).
Results.
A total of 3415 patients with DCIS were eligible.
Compared with HoR+/HER- subgroup, patients with triple-negative (TN) and HoR-/HER+ were commonly higher in grade, larger in size, and tended to receive mastectomy (P<0.05).
The multivariate analysis revealed that patients with TN were more likely to have a poorer OS and show a higher breast cancer-specific mortality compared with the HoR+/HER- subgroup (P<0.05).
Multivariate analysis on the history of local treatment and surgery showed patients receiving breast-conserving surgery (BCS) plus radiotherapy (R) and BCS plus axillary lymph node dissection was likely to improve OS without affecting breast cancer-specific mortality (P<0.05).
Conclusion.
The results demonstrate that DCIS associated with TN subtype portends poor prognosis.
Meanwhile, BCS plus R was a preferable option and resulted in survival rates better than those achieved with mastectomy, and SLNB should be considered as an appropriate assessment of axillary staging in patients with DCIS.
American Psychological Association (APA)
Liu, Yufei& Shou, Kangquan& Li, Juanjuan& Wu, Qi& Hu, Yuchang& Wang, Junjie…[et al.]. 2020. Ductal Carcinoma In Situ of the Breast: Perspectives on Tumor Subtype and Treatment. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136691
Modern Language Association (MLA)
Liu, Yufei…[et al.]. Ductal Carcinoma In Situ of the Breast: Perspectives on Tumor Subtype and Treatment. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136691
American Medical Association (AMA)
Liu, Yufei& Shou, Kangquan& Li, Juanjuan& Wu, Qi& Hu, Yuchang& Wang, Junjie…[et al.]. Ductal Carcinoma In Situ of the Breast: Perspectives on Tumor Subtype and Treatment. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136691