Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance
Joint Authors
Ganegoda, Gamage Upeksha
Liyanage, Kalupahana Irushi Pamodya
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diseases resulting from alterations in gene expressions through mutations in the genes or through changes in the gene expression regulation could be identified through the analysis of RNA expressions.
ncRNAs play a significant role in regulation of the gene expression by controlling the expression levels of the coding RNAs and other cellular processes.
Discoveries have shown that the human genome is encoded with sequences responsible for the transcription of thousands of ncRNAs.
Even though the studies conducted on ncRNAs are still at initial stages, facts established so far display biomarkers that confirm their relationship with certain diseases such as cancers, cardiovascular diseases, and insulin resistance.
These studies have been facilitated with high throughput modern sequencing techniques such as microarrays and RNA sequencing.
The data obtained through the above analysis are processed with the aid of existing databases, to deduce conclusions on different diagnostic biomarkers and therapeutic targets for specific diseases.
This review focuses on the association of ncRNAs in disease prediction, focusing mainly on cardiovascular diseases and disorders caused by insulin resistance.
The report also analyzes regulatory functions of ncRNAs and novel approaches used in disease therapeutics.
American Psychological Association (APA)
Liyanage, Kalupahana Irushi Pamodya& Ganegoda, Gamage Upeksha. 2017. Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136695
Modern Language Association (MLA)
Liyanage, Kalupahana Irushi Pamodya& Ganegoda, Gamage Upeksha. Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136695
American Medical Association (AMA)
Liyanage, Kalupahana Irushi Pamodya& Ganegoda, Gamage Upeksha. Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136695