The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis
Joint Authors
Tao, Ye
Wang, Ningning
Qiu, Tianming
Sun, Xiance
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Liver fibrosis is an intrinsic repair process of chronic injury with excessive deposition of extracellular matrix.
As an early stage of various liver diseases, liver fibrosis is a reversible pathological process.
Therefore, if not being controlled in time, liver fibrosis will evolve into cirrhosis, liver failure, and liver cancer.
It has been demonstrated that hepatic stellate cells (HSCs) play a crucial role in the formation of liver fibrosis.
In particular, the activation of HSCs is a key step for liver fibrosis.
Recent researches have suggested that autophagy and inflammasome have biological effect on HSC activation.
Herein, we review current studies about the impact of autophagy and NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome on liver fibrosis and the underlying mechanisms.
American Psychological Association (APA)
Tao, Ye& Wang, Ningning& Qiu, Tianming& Sun, Xiance. 2020. The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136710
Modern Language Association (MLA)
Tao, Ye…[et al.]. The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1136710
American Medical Association (AMA)
Tao, Ye& Wang, Ningning& Qiu, Tianming& Sun, Xiance. The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136710