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A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia
Joint Authors
Araki, Takeshi
Ohata, Shinya
Okamoto, Kohei
Morimoto, Kazuhide
Hiraishi, Mana
Yamada, Shinichiro
Mizuno, Ishikazu
Sugimoto, Takeshi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A 67-year-old male, with a known diagnosis of myelodysplastic syndromes with multilineage dysplasia (MDS-MLD) was admitted to our hospital with a primary complaint of subcutaneous bleeding in his left thigh.
Laboratory data showed anaemia and prolongation of activated partial thromboplastin time (85.8 s, normal range 24–39 s) without thrombocytopenia.
Coagulation factor VIII (FVIII) activity was less than 1% (normal range 60–150%), and a FVIII inhibitor was identified and quantified at 166 BU/mL to indicate a diagnosis of acquired haemophilia A (AHA).
A recent, but sustained circulating monocytosis (>1 × 109/L) was observed, which combined with elevated numbers of neutrophil and monocytic cells in the marrow, suggested evolution of MDS-MLD to chronic myelomonocytic leukaemia (CMML), coinciding with AHA.
Further analysis revealed a karyotype of 46, XY, i(14) (q10), which was the same abnormality previously identified in the patient.
To treat bleeding caused by AHA, steroid and activated prothrombin complex concentrate were administered.
Azacitidine (AZA) was used to treat CMML.
During the clinical course, bleeding partially improved; however, subsequent acute myocardial infarction occurred on day 87.
Worsening bone marrow failure was observed 4 months after the original admission, despite administration of AZA therapy, and the patient died due to bleeding from AHA.
This case suggests that the evolution of MDS to CMML status can be associated with AHA conferring a bleeding tendency.
American Psychological Association (APA)
Araki, Takeshi& Ohata, Shinya& Okamoto, Kohei& Morimoto, Kazuhide& Hiraishi, Mana& Yamada, Shinichiro…[et al.]. 2019. A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1136719
Modern Language Association (MLA)
Araki, Takeshi…[et al.]. A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia. Case Reports in Hematology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1136719
American Medical Association (AMA)
Araki, Takeshi& Ohata, Shinya& Okamoto, Kohei& Morimoto, Kazuhide& Hiraishi, Mana& Yamada, Shinichiro…[et al.]. A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1136719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136719