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SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis
Joint Authors
Harris, Edward N.
Natarajan, Vaishaali
Kidambi, Srivatsan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver fibrosis is a wound-healing response to chronic liver injury such as alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA-approved treatments.
Liver fibrosis results in a continual accumulation of extracellular matrix (ECM) proteins and paves the way for replacement of parenchyma with nonfunctional scar tissue.
The fibrotic condition results in drastic changes in the local mechanical, chemical, and biological microenvironment of the tissue.
Liver parenchyma is supported by an efficient network of vasculature lined by liver sinusoidal endothelial cells (LSECs).
These nonparenchymal cells are highly specialized resident endothelial cell type with characteristic morphological and functional features.
Alterations in LSECs phenotype including lack of LSEC fenestration, capillarization, and formation of an organized basement membrane have been shown to precede fibrosis and promote hepatic stellate cell activation.
Here, we review the interplay of LSECs with the dynamic changes in the fibrotic liver microenvironment such as matrix rigidity, altered ECM protein profile, and cell-cell interactions to provide insight into the pivotal changes in LSEC physiology and the extent to which it mediates the progression of liver fibrosis.
Establishing the molecular aspects of LSECs in the light of fibrotic microenvironment is valuable towards development of novel therapeutic and diagnostic targets of liver fibrosis.
American Psychological Association (APA)
Natarajan, Vaishaali& Harris, Edward N.& Kidambi, Srivatsan. 2017. SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136723
Modern Language Association (MLA)
Natarajan, Vaishaali…[et al.]. SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136723
American Medical Association (AMA)
Natarajan, Vaishaali& Harris, Edward N.& Kidambi, Srivatsan. SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136723