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Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo
Joint Authors
Zhang, Yunsheng
Liu, Luogen
Li, Fang
Wu, Tao
Jiang, Hongtao
Jiang, Xianxun
Du, Xiaobo
Wang, Yi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs).
However, the antitumor mechanism of salinomycin is unclear.
This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells.
We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1, and exposure to salinomycin induced G2/M phage arrest and apoptosis of PC-3 cells.
A mechanistic study found salinomycin suppressed Wnt/β-catenin pathway to induce apoptosis of PC-3 cells.
An in vivo experiment confirmed that salinomycin suppressed tumorigenesis in a NOD/SCID mice xenograft model generated from implanted PC-3 cells by inhibiting the Wnt/β-catenin pathway, since the total β-catenin protein level was reduced and the downstream target c-Myc level was significantly downregulated.
We also showed that salinomycin, but not paclitaxel, triggered more apoptosis in aldehyde dehydrogenase- (ALDH-) positive PC-3 cells, which were considered as the prostate cancer stem cells, suggesting that salinomycin may be a promising chemotherapeutic to target CSCs.
In conclusion, this study suggests that salinomycin reduces resistance and relapse of prostate tumor by killing cancer cells as well as CSCs.
American Psychological Association (APA)
Zhang, Yunsheng& Liu, Luogen& Li, Fang& Wu, Tao& Jiang, Hongtao& Jiang, Xianxun…[et al.]. 2017. Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136733
Modern Language Association (MLA)
Zhang, Yunsheng…[et al.]. Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1136733
American Medical Association (AMA)
Zhang, Yunsheng& Liu, Luogen& Li, Fang& Wu, Tao& Jiang, Hongtao& Jiang, Xianxun…[et al.]. Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1136733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136733