Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient
Joint Authors
Recher, Christian
Beziat, Guillaume
Tavitian, Suzanne
Picard, Muriel
Faguer, Stanislas
Huguet, Françoise
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
L-asparaginase is a key chemotherapeutic agent in acute lymphoblastic leukemia (ALL).
It is also known for multiple and severe specific toxicities, without consensual management.
We report the case of a 51-year-old man treated with L-asparaginase for recently diagnosed T-cell ALL.
During the treatment, he developed a coma due to multifactorial diffuse cerebral edema, by hepatic encephalopathy, cerebral venous thrombosis, and hyperammonemia, all linked to toxicity of L-asparaginase.
Specific and innovative treatments were employed to manage these toxicities: supplementation with L-carnitine, thiamine, and pyridoxine for hepatic toxicity, perfusion of sodium benzoate to decrease ammonemia, and extrahepatic albumin-based dialysis sessions, along with anticoagulation.
The patient improved within two weeks and is currently alive 13 months later, in first complete remission, without sequelae, on an alleviated chemotherapy regimen.
American Psychological Association (APA)
Beziat, Guillaume& Tavitian, Suzanne& Picard, Muriel& Faguer, Stanislas& Recher, Christian& Huguet, Françoise. 2019. Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1136743
Modern Language Association (MLA)
Beziat, Guillaume…[et al.]. Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient. Case Reports in Hematology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1136743
American Medical Association (AMA)
Beziat, Guillaume& Tavitian, Suzanne& Picard, Muriel& Faguer, Stanislas& Recher, Christian& Huguet, Françoise. Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1136743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136743