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Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia
Joint Authors
Kurita, Naoki
Yokoyama, Yasuhisa
Nishikii, Hidekazu
Shinagawa, Atsushi
Sakamoto, Tatsuhiro
Kusakabe, Manabu
Kato, Takayasu
Chiba, Shigeru
Nakamura, Naoya
Obara, Naoshi
Hasegawa, Yuichi
Sakata-Yanagimoto, Mamiko
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP.
Clinical remission was achieved, while B-cell clonality remained.
Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation).
However, autologous hematopoietic recovery occurred within a month after the transplant.
Nevertheless, B-cell clonality became undetectable at 14 days after transplant, which has been kept so for over 10 years with clinical remission.
Cytogenetic analyses were repeatedly performed and demonstrated nonclonal chromosomal aberrations, although the patient did not develop any secondary malignancies.
One possible explanation for the clinical course is a very short-term allogeneic immune reaction helping eradication of residual CLL cells.
American Psychological Association (APA)
Nishikii, Hidekazu& Kurita, Naoki& Shinagawa, Atsushi& Sakamoto, Tatsuhiro& Kusakabe, Manabu& Yokoyama, Yasuhisa…[et al.]. 2019. Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136772
Modern Language Association (MLA)
Nishikii, Hidekazu…[et al.]. Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. Case Reports in Hematology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1136772
American Medical Association (AMA)
Nishikii, Hidekazu& Kurita, Naoki& Shinagawa, Atsushi& Sakamoto, Tatsuhiro& Kusakabe, Manabu& Yokoyama, Yasuhisa…[et al.]. Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136772