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MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair
Joint Authors
Zhang, Zhiwei
Shao, Lianbo
Zhang, Yu
Lan, Beibei
Wang, Juanjuan
Zhang, Lulu
Xiao, Pengli
Meng, Qingyou
Geng, Yong-jian
Yu, Xi-yong
Li, Yangxin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) repair infarcted heart through paracrine mechanism.
We sought to compare the effectiveness of MSCs and MSC-derived exosomes (MSC-Exo) in repairing infarcted hearts and to identify how MSC-Exo mediated cardiac repair is regulated.
In a rat myocardial infarction model, we found that MSC-Exo inhibited cardiac fibrosis, inflammation, and improved cardiac function.
The beneficial effects of MSC-Exo were significantly superior compared to that of MSCs.
To explore the potential mechanisms underlying MSC-Exo’s effects, we performed several in vitro experiments and miRNA-sequence analysis.
MSC-Exo stimulated cardiomyocyte H9C2 cell proliferation, inhibited apoptosis induced by H2O2, and inhibited TGF-β induced transformation of fibroblast cell into myofibroblast.
Importantly, novel miRNA sequencing results indicated that MSC-Exo and MSCs have similar miRNA expression profile, which could be one of the reasons that MSC-Exo can replace MSCs for cardiac repair.
In addition, the expression of several miRNAs from MSC-Exo was significantly different from that of MSCs, which may explain why MSC-Exo has better therapeutic effect than MSCs.
In conclusion, this study demonstrates that MSC-Exo could be used alone to promote cardiac repair and are superior to MSCs in repairing injured myocardium.
American Psychological Association (APA)
Shao, Lianbo& Zhang, Yu& Lan, Beibei& Wang, Juanjuan& Zhang, Zhiwei& Zhang, Lulu…[et al.]. 2017. MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136790
Modern Language Association (MLA)
Shao, Lianbo…[et al.]. MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136790
American Medical Association (AMA)
Shao, Lianbo& Zhang, Yu& Lan, Beibei& Wang, Juanjuan& Zhang, Zhiwei& Zhang, Lulu…[et al.]. MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136790