Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro
Joint Authors
Ribeiro, Euler Esteves
Barbisan, Fernanda
Azzolin, Veronica F.
Mastella, Moisés H.
Teixeira, Cibele F.
Cruz, Ivana B. Mânica da
do Prado-Lima, Pedro Antonio Schmidt
Praia, Raquel de Souza
Medeiros Frescura Duarte, Marta Maria
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lithium (Li) is a chemical element used for treating and preventing bipolar disorder (BD) and exerts positive effects such as anti-inflammatory effects as well as undesirable side effects.
These effects of Li can be influenced by interaction with some nutritional elements.
Therefore, we investigated the potential effects of xanthine (caffeine and theobromine) and catechin molecules present in some food beverages broadly consumed worldwide, such as coffee and tea, on Li-induced anti-inflammatory effects.
In the present study, we concomitantly exposed RAW 264.7 macrophages to Li, isolated xanthine and catechin molecules, and a xanthine-catechin mixture (XC mixture).
We evaluated the effects of these treatments on cell proliferation, cell cycle progression, oxidative and antioxidant marker expression, cytokine levels, gene expression, and GSK-3β enzyme expression.
Treatment with the XC mixture potentialized Li-induced anti-inflammatory effects by intensification of the following: GSK-3β inhibitory action, lowering effect on proinflammatory cytokines (IL-1β, IL-6, and TNFα), and increase in the levels of IL-10 that is an anti-inflammatory cytokine.
Despite the controversial nature of caffeine consumption by BD patients, these results suggested that consumption of caffeine, in low concentrations, mixed with other bioactive molecules along with Li may be safe.
American Psychological Association (APA)
Barbisan, Fernanda& Azzolin, Veronica F.& Teixeira, Cibele F.& Mastella, Moisés H.& Ribeiro, Euler Esteves& do Prado-Lima, Pedro Antonio Schmidt…[et al.]. 2017. Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136794
Modern Language Association (MLA)
Barbisan, Fernanda…[et al.]. Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136794
American Medical Association (AMA)
Barbisan, Fernanda& Azzolin, Veronica F.& Teixeira, Cibele F.& Mastella, Moisés H.& Ribeiro, Euler Esteves& do Prado-Lima, Pedro Antonio Schmidt…[et al.]. Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136794